profile tfk corporation english

Company data

Company name	TFK Co., Ltd.
Address	1-2-25-D407, Wadayama-Dori, Hyogo-ku, Kobe-shi, Hyogo, 652-0884, JAPAN
Telephone	(+81)78-652-0203
FAX	(+81)78-652-8532
URL	https://www.tfk-corp.co.jp
E-mail	info@tfk-corp.co.jp
Establishment	March 21, 2001 (foundation: July 17, 1962)
Capital	70,000,000 yen
Representative	Chairman and CEO: Nobuhiro Toda
Number of employees	15
Principal bankers	Sumitomo Mitsui Asset Management Company, Ltd. The Bank of Tokyo-Mitsubishi UFJ, Ltd.
Businesses	Production and sales of health foods and functional labelling foods using microbe’s metabolites and cells. Research and development of medicines and functional labelling food using microbe’s metabolites and cells. Research and development of microbial energy. Research and development of biological diagnosis technique applying to soil, water and body. Research and development of marine resources. Research and development on production technology of agricultural products and marine products. All other subsidiary business related to business above.

Corporate History

March 2001	Established TFK Co., Ltd. as a sales company of Biochem Industry Co., Ltd. with 10 million yen in capital.
August 2001	Applied for a Japanese patent for our pharmaceutical product TFK.
October 2002	Acquired goodwill of Biochem Industry Co., Ltd.
October 2002	Started manufacturing and selling TFK as a health food.
March 2003	Acquired all industrial property rights of Biochem Industry Co., Ltd.
September 2003	Increased capital to 20 million yen.
March 2004	Started research and development of bio-clinic (medical information technology / blood analysis).
December 2004	Obtained US patent for health food TFK with the invention title “Rhodoseudomonas capsulatas strain No. BP-7434 for use in health foods.”
May 2005	Obtained patents for health food TFK in Singapore, Russia, Australia, and South Korea with the invention title “Rhodoseudomonas capsulatas strain No. BP-7434 for use in health foods.”
July 2005	Increased capital to 30 million yen.
October 2005	Started production of dietary supplement Bioban.
October 2005	Concluded a joint research agreement with the professor in charge of Tohoku Pharmaceutical University Cancer Research Institute Department 2 (currently Tohoku Medical and Pharmaceutical University Pharmacotherapy Department).
January 2006	Obtained a Chinese patent for health food TFK with the invention title “Rhodoseudomonas capsulatas strain No. BP-7434 for use in health foods.”
February 2006	Completion of a 90-day repeated oral administration toxicity test to examine the safety of TFK in animals.
February 2006	Published the results of the 90-day repeated oral toxicity study in rats in the February 2006 issue of Pharmacometrics (Japanese title “Oyo Yakuri”), Volume 70, No. 1/2. Based on these results, the no-observed-adverse-effect-level of our product was judged to be 1,000 mg/kg/day for both sexes.
March 2006	Increased capital to 40 million yen.
September 2006	Published the results of antitumor activity of Toda Fronty Koso (TFK), a functional food, against Sarcoma-180 in mice in the September 2006 issue of Pharmacometrics (Japanese title “Oyo Yakuri”), Volume 71, No. 1/2. Based on these results, the antitumor activity of TFK was confirmed.
September 2007	Increased capital to 50 million yen.
November 2007	Started production and sales of dietary supplement named Toda Koso.
February 2008	Started production and sales of health food named Sanju.
October 2008	Obtained a Japanese patent for health food TFK with the invention title “Rhodoseudomonas capsulatas strain No. BP-7434 for use in health foods.”
November 2010	Filed an international patent application with the invention title Preventive and/or ameliorative agent for diseases, physical endurance enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them.
May 2015	Obtained a Japanese patent for the invention name Preventive and/or ameliorative agent for diseases, physical endurance enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them.
July 2015	Obtained a Chinese patent for the invention title “Preventive and/or ameliorative agent for diseases, physical endurance enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them.”
December 2015	Obtained a Hong Kong patent for the invention title “Preventive and/or ameliorative agent for diseases, physical endurance enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them.”
March 2016	Obtained an EPC patent for the invention title “Preventive and/or ameliorative agent for diseases, physical endurance enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them.” The designated countries are United Kingdom, France, and Germany.
March 2016	Obtained a Korean patent for the invention title “Preventive and/or ameliorative agent for diseases, physical endurance enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them.”
April 2017	Applied for an international patent for the invention title “Agent for regulating composition ratio of intestinal bacterial flora, drug, food, drink and method for regulating composition ratio of intestinal bacterial flora.”
May 2017	Started production and sales of functional food named Kunju, non-denatured type II collagen.”
July 2017	Started production and sales of health food named Hyakkadama.
September 2017	Obtained a US patent for the invention title “Preventive and/or ameliorative agent for diseases, physical endurance enhancement agent, anti-fatigue agent, and pharmaceutical and food and drink using them.”
September 2017	Applied for an international patent for the invention title “Compound or salt thereof, anti-inflammatory agent, anticancer agent for lung cancer, method for producing compound or salt thereof, method for treating inflammatory disease, and method for treating lung cancer.”
September 2018	Increased capital to 70 million yen.
October 2018	Exhibited at “Bio Japan 2018.”
November 2018	A microbial mass culture bio-plant was completed at the head factory. The completion ceremony was held on November 16th.
February 2019	Published a paper in the scientific journal Carbohydrate Research, titled “Structural Analysis of Novel Lipooligosaccharides from Rhodobacter azotoformans.”
March 2019	Applied for an international patent for the invention title “Compound or salt thereof, anti-inflammatory agent, anticancer agent for lung cancer, method for producing compound or salt thereof, method for treating inflammatory disease, and method for treating lung cancer.”
June 2019	Attended a conference called the BIO International Convention 2019 in Philadelphia, USA.
February 2020	Obtained a Japanese patent for the invention title “Compound or salt thereof, anti-inflammatory agent, anticancer agent for lung cancer, method for producing compound or salt thereof, method for treating inflammatory disease, and method for treating lung cancer.”

History of Biochem Industrial Co., Ltd., from which we inherited all rights.

July 1962	Established Kyowa Co., Ltd. in Osaka with a capital of 1 million yen. The company was the sole distributor of infrared automatic hand wash basins in Japan.
May 1972	Nobuhiro Toda was appointed President of Kyowa Co., Ltd., succeeding former Representative Director Miyoji Hiraoka.
May 1972	Changed the business purpose to construction and became a national housing agency.
July 1972	Discovered the photosynthetic bacterium RAP99.
July 1974	Established the Institute for Microbial Research and embarked on joint research with Dr. Michiharu Kobayashi, from the Faculty of Agriculture at Kyoto University.
October 1980	Increased capital to 4 million yen.
July 1981	Established tertiary fermentation technology, which is a composting technology that can be applied to recycling livestock manure by fermenting bacteria named Teriyasu.
December 1982	Developed a technology to put the recycling of putrefactive organic matter into practical use, such as household garbage and materials for improving biological properties in soil.
January 1983	Increased capital to 10 million yen.
January 1983	Changed the company name to Biochem Industry Co., Ltd.
April 1983	Completely transformed our business into a biotechnology-related company, conducted a public experiment on the removal of heavy metals from wastewater by microorganisms, and started selling soil microbial improvement materials.
April 1983	Submitted a fertilizer sales business start notification to Hyogo prefecture. The registration number was 2058.
May 1983	Submitted a special fertilizer producer notification to Hyogo prefecture, with registration number 301. Started selling a fertilizer named Biosoil.
November 1983	Conducted a public experiment on the removal of heavy metals in wastewater using microorganisms (sponsored by the Ministry of International Trade and Industry, the Metal Mining Corporation, the Japan Mining Industry Association, and the Japan Industrial Technology Promotion Association).
January 1984	Started selling a fertilizer named Sunday Green registered by the Minister of Ordinary Fertilizer Producers (registration No. 70155).
December 1985	Built a compost plant in Ono City, Hyogo Prefecture.
July 1986	Applied for a utility model of the invention title “Sludge settling and purifying agent bag floating at the bottom of the sea, lakes, and ponds.”
June 1987	Signed a business contract for our Biosoil with the Economic and Agricultural Cooperative Association in Wakayama, Nara, and Kyoto Prefectures.
August 1987	Signed a business contract for our Biosoil with the Federation of Economic and Agricultural Cooperatives in Shiga, Mie, Osaka, and Hyogo prefectures.
April 1988	Developed a microbial remediation system for pond sewage.
June 1988	Developed a water remediation system for river water using microorganisms.
May 1990	Developed a system for improving continuous cropping of impaired soil on agricultural land.
June 1991	Developed a remediation system for aquaculture areas.
July 1990	Moved our head office from Kobe City to Ono City, in the Hyogo Prefecture.
August 1990	Developed a microbial fishing bank and completed a marine ranch system.
April 1991	Developed a water remediation system for aquaculture ponds.
September 1991	Developed a system that doubles the production of paddy rice without using pesticides or herbicides.
April 1992	Succeeded in a demonstration experiment in which sludge is decomposed by microorganisms in a closed sea area in Matoya Bay, in Mie Prefecture.
April 1992	Filed a Japanese patent application with the title of the invention “Sedimentation of sludge floating at the bottom of seas, lakes, and ponds, bags containing purifying agents.”
February 1993	Developed a fast-dissolved oxygen generator using a micro aerator.
March 1993	Developed a water purification device called the Biomachine.
May 1993	Applied for a Japanese patent with the invention title “Method for improving sediment/water quality and set of improving agent used for the method.”
December 1993	Filed a Japanese patent application with the invention title “Granular material extraction device.”
December 1993	Filed a Japanese patent application with the invention title “Water purification device.”
May 1993	Filed a Japanese patent application with the invention title “Gas-liquid mixer.”
January 1994	Succeeded in researching and developing the microbial food named Toda Fronty Koso (TFK).
February 1994	Developed a protein nutrient for animals, birds, and fish.
June 1994	Kwansei Gakuin University commended our pond purification technology by awarding us a shield.
July 1994	Moved our headquarters and research institute from Ono to Kobe.
July 1994	Filed a patent application in the United States based on a Japanese patent application from May 1993 with the invention title “Method for improving sediment and water quality and set of improving agents used for the method.”
January 1995	The Great Hanshin-Awaji Earthquake hit our headquarters and laboratory, burning them down.
February 1995	Obtained a US patent with the invention Title “Method for improving bottom and water quality in water areas and a set of agents used in the method.”
April 1995	Opened the Himeji Taishi Factory and restored part of our business.
June 1995	Completed the first high-concentration water purification device for factory wastewater and delivered it to Kobe City.
August 1995	Moved our head office and factory to the Seishin Industrial Park in Nishi-ku, Kobe, and started full-scale reconstruction activities.
October 1995	Obtained a US patent with the invention title “Agents used for improving the bottom and water quality in water areas where sludge is deposited.”
November 1996	Obtained a Japanese patent with the invention title “a bag containing a sludge sedimentation / purification agent floating at the bottom of the sea, lakes, and ponds.”
April 1996	Started clinical trials of health food and medicinal food TFK.
February 1997	Applied for an international patent for TFK as a health food and pharmaceutical product.
February 1997	Obtained a Japanese patent with the invention title “Method for improving sediment and water quality and a set of improving agents used in the method.”
September 2000	Obtained a Japanese patent with the invention Title “Gas-liquid mixer.”

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